Developing better drugs with our deep understanding of animal disease resistance
We’re harnessing the power of evolutionary biology, honed over 100 million years of evolution, to unlock mechanisms underlying disease resistance across species.
Why Fauna
Drugs fail when they are directed against the wrong targets. Many AI-native biotech companies looking for the right targets need to design and execute millions of wet lab experiments and generate petabytes of data, and spending >$100M to get assets to the clinic.
At Fauna, we let nature do the experiments over 100s of millions of years of optimization, creating an efficient discovery process that can get to in-vivo validation with less than $500K. We use the right data from the right species to get the right solutions to humankind's most challenging diseases.
Our pipeline
Discovery
Preclinical
IND-Enabling
Clinical
Partnered: 2023
Product
TRX103 (Treg)
(allo polyclonal,
off the shelf, non antigen-specific)
Indication
GvHD
Selection
Enabling
Product
TRX103 (Treg)
(allo polyclonal,
off the shelf, non antigen-specific)
Indication
Inflammatory bowel disease
Selection
Enabling
Product
TRX103 (Treg)
(allo polyclonal,
off the shelf, non antigen-specific)
Indication
Additional undisclosed indications
Selection
Enabling
Product
TRX319 (CAR Treg)
(allo polyclonal, off the shelf,
antigen-specific)
Indication
Multiple B-cell mediated AID
Selection
Enabling
Fauna Bio has data sets and early discovery programs across a broad range of diseases, including neurodegeneration, heart failure, kidney disease, GI disease and broad mechanisms relating to inflammation and fibrosis as well as tissue regeneration. Contact us to learn more about partnering with Fauna for discovery
Contact usConvergence™ AI, our proprietary platform, identifies and enriches human druggable targets across a wide range of disease areas.
We work directly with the Zoonomia Consortium, to produce a whole-genome alignment of 240 mammals, and protein-coding alignments for 428 mammals, recently featured in Science.
Orca
Identifies protective signatures in extreme animal datasets compared to human data
Centaur
Maps results to human genomics data and validates in human cell models
Leo
Predicts compounds to mimic natural protection using human cell lines
We’ve created the world’s largest biomedical knowledge graph integrating human data with animal disease resistance data as well as hundreds of curated functional genomics studies with RNA sequencing and proteomics.
We have collected thousands of transciptomes, proteomes, and epigenomes and over 46 billion sequence reads.
292
animals
24
tissues
21
time points
Comparative genomics is the study of similarities and differences in the DNA sequences of different species.
By comparing the genomes of diverse mammals, we can uncover long-term patterns of mutations that highlight the DNA bases crucial for survival. Due to the high genetic similarity among humans, even extensive datasets with tens of thousands of individuals often fail to reveal which specific bases are functional—most of the genome appears identical across all participants.
Learn more
